Diabetes' patients at higher colon cancer risk
Article page | Health page|
with diabetes face a more than doubled risk for some types of colorectal cancer,
according to a new research.
Diabetes has been identified as a colon cancer risk factor, but the mechanisms
arenít completely understood.
For this population-based cohort study, a research team, led by Mayo Clinic
physicians, examined data from 37,695 participants of the Iowa
Womenís Health Study (IWHS), which
enrolled women aged 55 in 1986 and remains ongoing.
Of these women, 2,361 reported a diagnosis of Type 2 diabetes and 1,200
developed colorectal cancer.
To find the links between colorectal cancer and diabetes, the researchers worked
with regional pathology laboratories to obtain tumor tissue samples from IWHS
participants who were diagnosed with colorectal cancer.
They linked the tissue samples with other IWHS data, looking for cancer pathways
and risk factors, and whether those risk factors were associated with three
different molecular markers: microsatellite instability (MSI), CpG island
methylation (CIMP), and BRAF gene mutations.
"Diabetes was more strongly associated with the MSI-high, CIMP-positive and BRAF-mutation
cancer subtypes in this group of older women," said Mayo Clinic
gastroenterologist Paul Limburg.
Limburg explained that diabetes appeared to confer a greater than twofold
increase in risk for these molecularly-defined tumors, compared to women without
The findings are being presented at Digestive Disease Week 2010, the annual
meeting of the American Gastroenterological Association.
- ANI / Times of India