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syndrome (WS), or DIDMOAD (diabetes insipidus, diabetes mellitus,
optic atrophy, and deafness), is a rare autosomal recessive
neurodegenerative disorder with a median life expectancy of 30 years
and occurs in one in 770,000 live births. To date only five
successful pregnancies have been reported among WS subjects
worldwide. Here we describe the sixth report of successful pregnancy
in a WS patient and the first from India. The subject is still on an
insulin pump, now 31 years old and doing well. She developed
diabetes at 5 years of age, optic atrophy at 14 years, and diabetes
insipidus at 25 years and had a successful delivery in 2007 while on
an insulin pump. Sequencing of exonic regions of the WFS1 gene
showed five changes, two of which were pathogenic (exon 8). Magnetic
resonance imaging of brain showed generalized neurodegenerative
changes. The benefits of continuous subcutaneous insulin infusion
and that of tight metabolic control in prevention of abortions and
fetal malformations in diabetes associated with pregnancy are well
documented. The impression of probable pleiotropic action of insulin
pumps over and above that of glycemic reduction is gaining momentum.
Recent evidence supports use of insulin pumps in alleviating
neuropathic pain in diabetes, probably by virtue of its action in
minimizing mean amplitude of glycemic excursions not possible with
conventional insulin shots. WS is a progressive neurodegenerative
disorder, which will probably help us in understanding the positive
impact of continuous subcutaneous insulin infusion in prolonging the
life span and retarding neuronal damage in WS.
High-fat diet, though dangerous may reverse
diabetes-related kidney damage.
Renal failure, one of the
main complications of diabetes, may reverse in eight weeks by ketogenic diet.
According to a mice study conducted at Sinai Hospital in New York, Ketogenic
diet of high fatty food starves the body of carbs and sugars, thereby tricking
the body into burning fat for fuel instead of glucose.
The researchers took two groups of mice that were genetically predisposed to
having Type 1 or Type 2 diabetes. Half were fed a standard, high-carb diet while
the other half received a ketogenic diet.
After eight weeks, kidney failure was reversed in the ketogenic-fed mice,
said Lead author Charles Mobbs, a neuroscientist at the Mount Sinai Medical
Word of caution: This is only an initial observation. Kidney disease
patients should strictly adhere to the diet advised by their treating doctor and
dietitian (JDC Gems editorial team).
Decreased vitamin D levels connected to diabetes risk.
People with lower levels
of vitamin D circulating in their bloodstream are at higher risk of developing
diabetes, reveals a study, which followed more than 5,000 people for 5 years.
Researchers found that those, with lower than average vitamin D levels had a 57%
increased risk of developing type 2 diabetes compared to people with levels in
the recommended range.
"Studies like ours have suggested that blood levels of vitamin D higher
than what is recommended for bone health may be necessary to reduce the risk of
developing type 2 diabetes," said lead author Dr. Claudia Gagnon, a fellow at
the Western Hospital at the University of Melbourne in Australia where the study
To check whether circulating D levels and calcium consumption influenced
insulin sensitivity and diabetes risk, Gagnon's team measured the vitamin D
blood levels of 5,200 people without diabetes. After 5 years, about 200 of them
had developed diabetes, and the researchers measured everyone's vitamin D levels
The researchers found that twice as many people (6 in 100) with low blood
levels of vitamin D later developed diabetes, compared to those with blood
levels in the normal range (3 in 100
to be slim? Avoid obese friends
A new study
found that obese friends can also make you fatter. According to this study
thin people who socialise with the obese can put on weight. But, here is the
good news. The process can work in reverse too theoretically , says the
study. The researchers Nicholas Christakis and James Fowler, examined 32
years of data collected during a research of people's hearts in Framingham
in Massachusetts . They discovered that where two people who are friends for
a long time, and where one is heavier than the other, the thinner friend
tended to increase in weight by up to 57% over time.
Compound in Broccoli May Block Defective Gene Linked to
You may have heard that
broccoli and other cruciferous vegetables such as cauliflower and watercress has
the ability to fight against cancer. But until now the scientists did not know
the secret behind the vegetables' anticancer attributes.
Diabetes Medicine Updates
In a new study, researchers found compounds in broccoli and other
cruciferous vegetables called isothiocyanates (ITCs) appear to target and block
mutant p53 genes associated with cancer growth.
Gene p53 is known as a tumor suppressor gene and appears to play a critical
role in keeping cells healthy and protecting them from cancer. When this gene is
damaged or mutated, it stops offering this protection. Researchers say these
mutations are found in about half of all human cancers.
In a report published in the Journal of Medicinal Chemistry, researcher
Xiantao Wang of Georgetown University and colleagues analyzed the effects of
ITCs on gene p53 in a variety of human cancer cells, including lung, breast, and
colon cancer, in the lab.
The results showed that ITCs were capable of removing the defective p53
gene while leaving healthy versions of the gene alone.
approves new treatment for Type 2 diabetes
U.S. Food and Drug Administration approved Tradjenta (linagliptin) tablets, used
with diet and exercise, to improve blood glucose control in adults with Type 2
diabetes. Tradjenta increases the level of hormones that stimulate the release
of insulin after a meal by blocking the enzyme dipeptidyl peptidase-4 or DPP-4,
which leads to better blood glucose control.
Tradjenta was demonstrated to be safe and
effective in eight double-blind, placebo-controlled clinical studies involving
about 3,800 patients with Type 2 diabetes. The studies showed improvement in
blood glucose control compared with placebo. The most common side effects of
Tradjenta are upper respiratory infection, stuffy or runny nose, sore throat,
muscle pain, and headache.
Reference: The newsletter published by Jothydev's Diabetes
Centre for free distribution through the Internet for doctors, patients and
public for promoting healthy lifestyles. For enquiries, please contact: Sunitha
Jothydev, CAO, Jothydev's Diabetes Centre, Trivandrum -